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Changes induced in the gills of milkfish (Chanos chanos Forsskål) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138)

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Date
1995
Author
Tamse, Catherine T.
Gacutan, Rogelio Q.
Tamse, Armando F.
Page views
1,764
ASFA keyword
antibiotics ASFA
aquaculture ASFA
drug resistance ASFA
drugs ASFA
fish culture ASFA
gills ASFA
histology ASFA
histopathology ASFA
intensive aquaculture ASFA
lethal limits ASFA
pathogens ASFA
toxicity tests ASFA
AGROVOC keyword
acute toxicity AGROVOC
animal pathology AGROVOC
antimicrobial agents AGROVOC
salmon AGROVOC
tissue analysis AGROVOC
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Abstract
The need for a chemotherapeutant used specifically for fish disease became increasingly apparent with intensive fish culture practices, and with the possibility of bacterial resistance against drugs used for human and animal medicine (Austin 1985). With this in mind, Nifurpirinol (trade name Furanace; P-7138) was developed by the Dainippon Pharmaceutical Co., Ltd., Japan, and is currently manufactured in the United States as Prefuran. Studies have proven that the drug is effective against bacterial and fungal pathogens in a wide variety of aquatic animals. Most of the Nifurpirinol studies done in the past have dealt on its antimicrobial activity, tissue uptake, and effective treatment levels ranging from 0.5-2.5 mg/L. The 96-hr median lethal concentration (LC50) to channel catfish (Ictalurus punctatus Rafinesque) has also been determined at 0.945-1.90 mg/L, and at 1.70 mg/L for milkfish, Chanos chanos Forsskaal. However, there have only been two studies that have examined the histological effects on treated fish. Histopathologically, Mitchell et al. (1978) found hypertrophy and hyperplasia of the lamellar epithelium in channel catfish gills exposed to 0.5 mg/L for 4 d or longer at 24 plus or minus 2 degree C, while Amend and Ross (1970) working at 21 plus or minus 1 degree C observed no apparent changes in the gills of coho salmon (Oncorhynchus kisutch) exposed intermittently to 1 mg/L of Nifurpirinol. This paper describes the histological changes observed in the gills of milkfish fingerlings used in static, 96-hr Nifurpirinol toxicity tests. Milkfish was used because of its economic importance as a widely cultured food fish in Asia. The gills were chosen as target organs.
URI
http://hdl.handle.net/10862/1496
Suggested Citation
Tamse, C. T., Gacutan, R. Q., & Tamse, A. F. (1995). Changes induced in the gills of milkfish (Chanos chanos Forsskål) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138). Bulletin of Environmental Contamination and Toxicology, 54(4), 591-596. https://doi.org/10.1007/BF00192604 
DOI
10.1007/BF00192604
Type
Article
ISSN
0007-4861
Collections
  • Journal Articles [1183]


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