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dc.contributor.authorGapasin, R. S. J.
dc.contributor.authorNelis, H. J.
dc.contributor.authorChair, M.
dc.contributor.authorSorgeloos, P.
dc.date.accessioned2013-04-08T06:05:32Z
dc.date.available2013-04-08T06:05:32Z
dc.date.issued1996
dc.identifier.citationGapasin, R. S. J., Nelis, H. J., Chair, M., & Sorgeloos, P. (1996). Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation. Journal of Applied Ichthyology, 12(1), 39–42.en
dc.identifier.issn0175-8659
dc.identifier.urihttp://hdl.handle.net/10862/1558
dc.description.abstractAssimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (Dicentrarchus labrax) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in an oil emulsion (Selco) at 20 % and 40 % concentrations (w/w) were bioencapsulated in Artemia (Instar II) nauplii. Chemotherapeutics-loaded ('medicated) nauplii were fed to the sea bass fry and drug concentrations in the tissue were analysed by high-performance liquid chromatrography (HPLC). Fish fed 40 %'medicated Artemia assimilated significantly higher levels of chemotherapeutics compared with those fed 20 %'medicated' Artemia. Chemotherapeutics given at 40 % reached peak levels (19.3 μg TMP/g DW and 23.31 μg SMX/g DW) within 2 h while those at 20 % peaked (8.74 μg TMP/g DW and 6.73 fig SMX/g DW) after 5 h. TMP persisted in the tissues longer (up to 72 h) than SMX (12–16 h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectDicentrarchus labrax
dc.titleDrug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulationen
dc.typeArticleen
dc.identifier.doi10.1111/j.1439-0426.1996.tb00057.x
dc.citation.volume12
dc.citation.issue1
dc.citation.spage39
dc.citation.epage42
dc.citation.journalTitleJournal of Applied Ichthyologyen
seafdecaqd.library.callnumberVF SJ 0512
seafdecaqd.databank.controlnumber1996-05
dc.subject.asfaAnimal metabolismen
dc.subject.asfaAntibioticsen
dc.subject.asfaCage cultureen
dc.subject.asfaChromatographic techniquesen
dc.subject.asfaFood conversionen
dc.subject.asfaFryen


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