Perlihatkan publikasi sederhana

dc.contributor.authorDunlap, Paul V.
dc.contributor.editorLavilla-Pitogo, Celia R.
dc.contributor.editorCruz-Lacierda, Erlinda R.
dc.date.accessioned2021-10-15T07:58:36Z
dc.date.available2021-10-15T07:58:36Z
dc.date.issued2002
dc.identifier.citationDunlap, P. V. (2002). Quorum sensing and its potential application to vibriosis. In C. R. Lavilla-Pitogo & E. R. Cruz-Lacierda (Eds.), Diseases in Asian aquaculture IV: Proceedings of the Fourth Symposium on Diseases in Asian Aquaculture, 22-26 November 1999, Cebu City, Philippines (pp. 59-71). Fish Health Section, Asian Fisheries Society.en
dc.identifier.isbn9718020160
dc.identifier.urihttp://hdl.handle.net/10862/6196
dc.description.abstractQuorum sensing is a gene regulatory mechanism by which certain pathogenic and symbiotic bacteria respond to population density and host association. By mediating the ability of bacteria such as Vibrio harveyi to infect larval shrimp, quorum sensing could have application to the problem of vibriosis in shrimp mariculture. Knowledge of quorum sensing developed from studies of luminescence in the marine bacteria Vibrio fischeri and V. harveyi. In both species, luminescence is controlled by a quorum-sensing mechanism involving two signal molecules and several genetically defined and physiological factors. In V. fischeri, luminescence is regulated by LuxR protein and the Luxl-dependent 3-oxo-hexanoyl-homoserine lactone (3- oxo-C6-HSL), which together activate transcription of luxICDABEG (the lux operon, genes for LuxI and the luminescence enzymes). A second acyl-HSL, octanoyl-HSL, product of AinS, blocks premature lux operon induction by interfering with 3-oxo-C6-HSL binding to LuxR. In V. harveyi, quorumsensing control of luminescence involves the luxLM-dependent 3-hydroxy- butyryl-HSL and an unidentified luxS-dependent signal molecule. These signals, through independent branches of a phosphorylation cascade, control the phosphorylation state of LuxO. In the absence of the signals, LuxO, in phosphorylated form, represses lux operon (luxCDABEGH) expression. The presence of the signals operates to dephosphorylate LuxO, relieving the repression. A LuxR protein then activates lux operon transcription. Targets for blocking the quorum-sensing mechanism in these bacteria and potentially blocking vibriosis include the activity, production and persistence of the signals, the production and activity of the response proteins, and the activity of specific downstream quorum-sensing controlled proteins involved in host infection.en
dc.publisherFish Health Section, Asian Fisheries Societyen
dc.subjectPenaeus monodonen
dc.subjectprawns and shrimpsen
dc.subjectQuorum sensingen
dc.titleQuorum sensing and its potential application to vibriosisen
dc.typeConference paperen
dc.citation.spage59en
dc.citation.epage71en
dc.citation.conferenceTitleDiseases in Asian aquaculture IV: Proceedings of the Fourth Symposium on Diseases in Asian Aquaculture, 22-26 November 1999, Cebu City, Philippinesen
dc.subject.asfavibriosisen
dc.subject.asfaluminescenceen
dc.subject.scientificNamePenaeus monodonen
dc.subject.scientificNameVibrio harveyien
dc.subject.scientificNameVibrio fischerien


Files in this item

FilesSizeFormatView

There are no files associated with this item.

Publikasi ini ada di koleksi berikut

Perlihatkan publikasi sederhana