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    Controlled release of testosterone and estradiol-17 β from biodegradable cylinders

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    Date
    1994
    Author
    Zhang, X.
    Wyss, U.P.
    Pichora, D.
    Goosen, M.F.A.
    Gonzal, A.
    Marte, Clarissa L.
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    Abstract
    A controlled release device for the hormones, testosterone and estradiol-17 β, was developed by coating a melt extruded hormone/poly (ϵ-caprolactone) cylinder with pure polylactide. Since testosterone and estradiol-17β have much higher permeabilities in poly (ϵ-caprolactone) than in polylactide, they primarily permeate through the open ends of the cylinder, with little release through the polylactide wall. By changing the cylinder length, the release rate and duration could be adjusted. The release followed Pick's diffusion equation for a drug loading below its solubility in poly (ϵ-caprolactone) or Higuchi's equation for a drug loading above the solubility. The diffusion coefficients of testosterone and estradiol-17β in poly (ϵ-caprolactone) were estimated as \((8.31 \pm 3.12) \times 10^{−18}\) and \((0.728 \pm 0.250) \times 10^{-18} cm^{2}/s\), respectively.
    URI
    http://hdl.handle.net/10862/1467
    Suggested Citation
    Zhang, X., Wyss, U. P., Pichora, D., Goosen, M. F. A., Gonzal, A., & Marte, C. L. (1994). Controlled release of testosterone and estradiol-17 β from biodegradable cylinders. Journal of Controlled Release, 29(1-2), 157-161.
    DOI
    10.1016/0168-3659(94)90131-7
    Type
    Article
    ISSN
    0168-3659
    Subject
    Testosterone; Estradiol-17 β; Biodegradable cylinder; Diffusion coefficient
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    • Journal Articles [1108]


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