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dc.contributor.authorZhang, X.
dc.contributor.authorWyss, U.P.
dc.contributor.authorPichora, D.
dc.contributor.authorGoosen, M.F.A.
dc.contributor.authorGonzal, A.
dc.contributor.authorMarte, Clarissa L.
dc.date.accessioned2013-02-21T09:16:59Z
dc.date.available2013-02-21T09:16:59Z
dc.date.issued1994
dc.identifier.citationZhang, X., Wyss, U. P., Pichora, D., Goosen, M. F. A., Gonzal, A., & Marte, C. L. (1994). Controlled release of testosterone and estradiol-17 β from biodegradable cylinders. Journal of Controlled Release, 29(1–2), 157–161.en
dc.identifier.issn0168-3659
dc.identifier.urihttp://hdl.handle.net/10862/1467
dc.description.abstractA controlled release device for the hormones, testosterone and estradiol-17 β, was developed by coating a melt extruded hormone/poly (ϵ-caprolactone) cylinder with pure polylactide. Since testosterone and estradiol-17β have much higher permeabilities in poly (ϵ-caprolactone) than in polylactide, they primarily permeate through the open ends of the cylinder, with little release through the polylactide wall. By changing the cylinder length, the release rate and duration could be adjusted. The release followed Pick's diffusion equation for a drug loading below its solubility in poly (ϵ-caprolactone) or Higuchi's equation for a drug loading above the solubility. The diffusion coefficients of testosterone and estradiol-17β in poly (ϵ-caprolactone) were estimated as \((8.31 \pm 3.12) \times 10^{−18}\) and \((0.728 \pm 0.250) \times 10^{-18} cm^{2}/s\), respectively.en
dc.language.isoenen
dc.publisherControlled Release Societyen
dc.subjectEstradiol-17 βen
dc.subjectBiodegradable cylinderen
dc.subjectDiffusion coefficienten
dc.titleControlled release of testosterone and estradiol-17 β from biodegradable cylindersen
dc.typeArticleen
dc.identifier.doi10.1016/0168-3659(94)90131-7
dc.citation.volume29
dc.citation.issue1-2
dc.citation.spage157
dc.citation.epage161
dc.citation.journalTitleJournal of Controlled Releaseen
seafdecaqd.library.callnumberVF SJ 0476
seafdecaqd.databank.controlnumber1994-48
dc.subject.asfatestosteroneen


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  • Journal Articles [1215]
    These papers were contributed by Department staff to various national and international journals.

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